Gamma Globulins in Germ-free Rats
نویسندگان
چکیده
The electrophoretic fractions of serum proteins were studied up to the 5th generation in a colony of germ-free rats. The germ-free animals had significantly lower concentrations of beta and the gamma globulins, while the other fractions were within normal limits. Assuming that the gamma globulins survive equally long in the circulation in germ-free animals as in controls, the production of gamma globulins in normal rats is three times as rapid as in germ-free rats. This suggests that the normal flora of microorganisms is an important stimulant for the gamma globulin-producing cells.
منابع مشابه
Gamma Globulin Production in Germfree Rats after Bacterial Contamination
The earlier observed pronounced hypogammaglobulinemia in germfree rats of different ages has been confirmed. Using an immunologic technique the concentration of immunologic gamma globulins were found to vary between 10 and 15 per cent of the values observed in ordinary rats. Upon contamination of germfree rats with the normal microbial flora a pronounced lag phase was noted before the gamma glo...
متن کاملEffect of various modifications in the diet on ileal epithelium renewal in germ-free and conventional rats.
Renewal of the ileal epithelium has been studied in germ-free (GF) and conventional (CV) rats fed with a semi-synthetic diet in the following forms: a) pellets sterilized by autoclaving (Pel. Au. diet); b) powder sterilized by gamma irradiation; when given to the rats, its weight in water was added to make a paste (Pa. I. diet); c) powder treated as (b) but with 10 p. 100 lactose added (L. Pa. ...
متن کاملReduced lectin stimulation of lymphocytes from magnesium-deficient rats.
Spleen cells and thymocytes from Mg-deficient rats, fed a Mg-deficient diet for 10--13 weeks, incorporate [3H]thymidine at half the rate of normal cells. The cells from Mg-deficient rats are less stimulated by lectins than those from normal animals. These effects correspond to the reduced content of gamma-globulins in serum in Mg deficiency. They are caused by the altered electrolyte content of...
متن کاملIs the efficacy of Chinese herbal medicine on polycystic ovarian syndrome enhanced by acupuncture in rats?
The objective of the present study is to investigate whether acupuncture could significantly enhance the efficacy of Chinese herbal medicine (CHM) in treating polycystic ovarian syndrome (PCOS) rats by testosterone propionate. Forty female Sprague–Dawley rats were equally divided into normal control group (Group A), model group (Group B), CHM combined with acupuncture group (Group C) and CHM gr...
متن کاملDifferences between germ-free and conventional rats in liver microsomal metabolism of steroids.
The metabolism of some steroids has been investigated in liver microsomal preparations from male germ-free and conventional rats. Hydroxylation of 4-[4-14C]androstene3,17-dione in positions 60 and 16~~ is about 2 and 1.5 times more efficient in germ-free than in conventional rats. The same is true for 6/3and Zol-hydroxylation of 4-[4J4C]pregnene-3,20-dione (about 1.6 and 1.2 times larger, respe...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- The Journal of Experimental Medicine
دوره 108 شماره
صفحات -
تاریخ انتشار 1958